One of the most striking statements that came from Anthony Weiner's press conference admitting he lied about not sending pictures to people was his clear denial he was going to resign. That, however, doesn't prevent people from both sides of the aisle from saying he should. Regardless of your political affiliation, it's entirely possible Weiner could reconsider for a number of reasons.
1) It creates an issue for Republicans to use in campaign ads. The timing of the Weiner scandal may not seem to be all that important to the 2012 campaign, but the longer it goes on, the more likely it becomes an issue that can be used, especially if the details are more and more salacious. At a time when Democrats are hoping to take back the House and keep the Senate and White House, a resolution to Weinergate can't come soon enough for them.
2) Weiner committed an unpardonable sin. No, I'm not talking about lying about the photos. The unpardonable sin Weiner committed is he allowed party bigwigs to unknowingly lie on his behalf. That alone cost him some support with Democrat leadership. With a looming House Ethics Committee investigation, it may buy Weiner a little time to change his mind, but it would be difficult to count on much Democrat support for him to keep his job at this point.
3) Weiner made Leftists look foolish. As predictable as ever, the Left came out in force to defend Weiner and attack Andrew Breitbart. There are some who still defend Weiner to this day, even though in the larger perspective, he's used them to provide temporary cover. To their credit, some of those Weiner defenders are coming clean and admitting they were duped and angry at Weiner for making them look foolish. The longer this scandal goes on, you can count on the erosion of Weiner's support from his grassroots, and that can have a negative impact on the party.
4) The media will keep Weinergate going. Weinergate has the perfect storm of media attention: sex, lies, social media, attractive women, a politician, and endless numbers of jokes that can be made. If that's not enough to make Weiner reconsider, nothing will be.
5) The "sympathy card" is being played. Whenever there's a sexual scandal involving a prominent politician, the focus expands to include those indirectly involved with the scandal. Weiner's wife, Huma, has become a public figure in the wake of the scandal, and that in and of itself can create a strain that can ruin her marriage and her life. That, in turn, creates sympathy or Huma and makes Weiner look even worse, especially if the rumors are true that Huma is pregnant. That won't end well for anyone.
Although this list isn't comprehensive by any stretch of the imagination, these five points lead me to believe Weiner may be resigning sometime in the future. It's a matter of whether Weiner sees the signs and when he decides to take (or not take) action.